Incubator Accessories
Diagnostic Biosystems ANTI-ISOCITRATE DEHYDROGENENAS Anti-Isocitrate Dehydrogenenase 1 (IDH1)-R132S
Isocitrate dehydrogenase 1 (IDH1) is a 46 kDa NADP-dependent enzyme, which catalyzes the decarboxylation of isocitrate into α-ketoglutarate. IDH1 may also play a role in the prevention of oxidative damage, and the shuttling of proteins to peroxisomes. It is widely reported that mutations in IDH1 result in multiple forms of gliomas. The Arginine to Serine substitution at amino acid 132 is seen in gliomas, abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alphaketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2- hydroxyglutarate.
Diagnostic Biosystems C-MYC C-myc
This antibody recognizes a transcription factor of 64-67kDa, identified as c-myc. Its epitope spans between aa 410-419 (EQKLISEEDL) which is a specific portion of an alpha helical region of human c-myc protein. This antibody shows no cross-reaction with v-myc. c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or over expressed in a variety of tumors. Over-expression of c-myc protein occurs frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease.
Diagnostic Biosystems CHROMOGRANIN A Chromogranin A
Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.
Diagnostic Biosystems MUCIN 5AC Mucin 5AC/Gastric Mucin
This antibody reacts with a 1000 kDa protein and recognizesthe peptide core of gastric mucin M1. Mucins are high molecular weight glycoproteins with 80% carbohydrates and 20% core protein. Gastric mucin M1 antigen is found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in normal colon. Resurgence of gastric mucin during colonic carcinogenesis is suggestive of either reexpression of the peptide core of gastric mucin in the adult colon or changes in the glycosylation pattern of mucin, which expose the hidden M1 antigen.
Hach Company SC1000 Mod-6 SensorModbus 485
SC1000 Probe Module-6 Sensor Connectors-Modbus 485-4 Relays-100-240 VAC with ConduitsIncludesSC1000 Probe Module with installed cards (as requested)-Basic User Manual
Diagnostic Biosystems CADHERIN 17 Cadherin 17
Cadherin 17 is exclusively expressed in the epithelial cells of embryonic and adult small intestine, colon, liver, and pancreatic ducts. It has been reported to be frequently expressed in adenocarcinomas arising in the gastrointestinal tract and pancreas. Owing to its restricted expression in these groups of tumors, cadherin 17 has proven to be a useful immunohistochemical marker for assisting in distinguishing these neoplasms from other malignancies with which they may be confused
Diagnostic Biosystems PNEUMOCYSTIS Pneumocystis
The Pneumocystis Stain Kit is intended for use in the histological visualization of Pneumocystis carinii in cytology smears, and paraffin or frozen tissue sections.
Diagnostic Biosystems SATB2 SATB2 (EP 281)
Special AT-rich sequence-binding protein 2 (SATB2) is a recently described marker that functions as a nuclear matrix-associated transcription factor. It has been reported that SATB2, in combination with CK20, could identify almost all colorectal carcinomas, including poorly differentiated colorectal carcinomas. Upper gastrointestinal (GI) carcinomas and pancreatic ductal carcinomas are usually negative for SATB2, and ovarian carcinomas, lung adenocarcinomas, and adenocarcinomas from other origin are rarely positive for SATB2. Therefore, SATB2 is a good marker for identifying a carcinoma of colorectal origin when working on a tumor of unknown primary. It can help differentiate colorectal metastasis (SATB2+) from primary pulmonary adenocarcinoma of mucinous or enteric type (SATB2- but often CDX2+)\n
Diagnostic Biosystems PTAH PTAH
The PTAH Stain Kit is intended for use in the histological visualization of collagen, striated muscle, glial fibers and collagen without using Zenker’s Fixative containing Mercuric Chloride. This kit may be used on formalin-fixed, paraffin-embedded or frozen sections.
Perkin Elmer US LLC TCD Add-On Kit - 230 V Clarus, Manual Pneumatics
Kit includes all necessary items to install the TCD into the instrument:detector, heater, sensor, heater block, 1/16 in. gas line, and flow controller pneumatics. Requires, but does not include, amplifier (N6120015). The TCD can only be installed in the rear detector position.
Diagnostic Biosystems SATB2 SATB2 (EP 281)
Special AT-rich sequence-binding protein 2 (SATB2) is a recently described marker that functions as a nuclear matrix-associated transcription factor. It has been reported that SATB2, in combination with CK20, could identify almost all colorectal carcinomas, including poorly differentiated colorectal carcinomas. Upper gastrointestinal (GI) carcinomas and pancreatic ductal carcinomas are usually negative for SATB2, and ovarian carcinomas, lung adenocarcinomas, and adenocarcinomas from other origin are rarely positive for SATB2. Therefore, SATB2 is a good marker for identifying a carcinoma of colorectal origin when working on a tumor of unknown primary. It can help differentiate colorectal metastasis (SATB2+) from primary pulmonary adenocarcinoma of mucinous or enteric type (SATB2- but often CDX2+)\n
Diagnostic Biosystems MUCICARMINE Mucicarmine
Mucicarmine Stain Kit is intended for use in the histological visualization of acid mucopolysacharides in tissue sections. This product is useful in distinguishing mucin negative undifferentiated squamous cell lesions from mucin positive adenocarcinomas. In addition, this product will stain the mucopolysaccharide capsule of Cryptococcus neoformans.